LXQ-87 | PTP1B inhibitor | Probechem Biochemicals

Chemical Structure : LXQ-87

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LXQ-87 (LXQ87)

货号: PC-27109Not For Human Use, Lab Use Only.

LXQ-87 is a selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B/PTPN1) with IC50 of 1.06 uM, displays excellent selectivity over TCPTP and SHP-2.

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生物&药学活性

LXQ-87 is a selective, orally active, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B/PTPN1) with IC50 of 1.06 uM, displays excellent selectivity over TCPTP and SHP-2.
educes the fasting blood glucose level and improves glucose tolerance and dyslipidemia in BKS db/db mice suffering from T2DM.
LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake by directly binding to intracellular PTP1B.
LXQ-87 exhibits potent antiproliferative effects across a range of cancer cell lines.
LXQ-87 initiates intrinsic mitochondrial apoptosis, causes G0/G1 phase arrest through decreased Cyclin D1/CDK4/6/c-Myc expression, curbs cell migration, and raises reactive oxygen species (ROS) levels, LXQ-87 also reduces STAT3 phosphorylation.

物理化学性质&存储条件

分子量	534.20
分子式	C23H18Br2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,3-dibromo-4,5-dihydroxyphenyl)-1-(4-(4-ethoxyphenoxy)phenyl)prop-2-en-1-one

参考文献

1. Gao C, et al. Eur J Med Chem. 2025 Jan 15;282:117053.

2. Xu F, et al. Bioorg Chem. 2026 Jun 18;180:110127.

LXQ-87 (LXQ87)

生物&药学活性

物理化学性质&存储条件

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LXQ-87 (LXQ87)

生物&药学活性

物理化学性质&存储条件

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