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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-EYA2-IN-1
EYA2-IN-1

Chemical Structure : EYA2-IN-1

CAS No.: 3105968-26-8

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EYA2-IN-1

货号: PC-27140Not For Human Use, Lab Use Only.

EYA2-IN-1 is a specific, small molecule allosteric EYA2 inhibitor with IC50 of 0.36 uM, inhibits cell growth of medulloblastoma cell line D458 with GI50 of 1.9 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EYA2-IN-1 is a specific, small molecule allosteric EYA2 inhibitor with IC50 of 0.36 uM, inhibits cell growth of medulloblastoma cell line D458 with GI50 of 1.9 uM.
EYA2-IN-1 shows weak to no inhibition against EYA3 and EYA4, PTP1B and Scp1.

物理化学性质&存储条件

分子量 357.42
分子式 C17H12FN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3-fluoro-N'-((5-(pyridin-2-ylthio)thiophen-2-yl)methylene)benzohydrazide

参考文献

1. Lukas Gardner, et al. ChemMedChem. 2024 Sep 16;19(18):e202400179.

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