| Cat. No. |
Product Name |
Information |
| PC-25514 |
KGP265
Tubulin inhibitor
|
KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18. |
| PC-25513 |
OXi6197
Tubulin inhibitor
|
OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase. |
| PC-25512 |
OXi6196
Tubulin inhibitor
|
OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay. |
| PC-25427 |
VASH1-VASH2 inibitor LV87
VASH1/2 inhibitor
|
LV87 is a potent, selective and covalent inhibitor of tubulin detyrosinating enzymes VASH1 and VASH2 with IC50 of 0.01 and 0.06 uM respectively, inhibits tubulin detyrosination. |
| PC-25361 |
Tubulin inhibitor 89
Tubulin inhibitor
|
Tubulin inhibitor 89 is a novel potent colchicine-site inhibitor of tubulin, has significant cytostatic activity against human Hela (cervical) and HCT116 (colonic) tumor cells with IC50 of 1.13 and 0.65 uM respectively, interferes with the assembly of microtubules by inhibiting PI3K/Akt signaling pathway. |
| PC-24654 |
RGN6024
Tubulin destabilizer
|
RGN6024 is a brain-penetrant, small molecule tubulin destabilizer, binds the colchicine binding site of tubulin, displays high potency against GB cell lines. |
| PC-24416 |
Tubulin inhibitor No.07
Tubulin inhibitor
|
Tubulin inhibitor No.07 is a novel tubulin inhibitor, irectly binds to tubulin dimers and interferes with microtubule polymerization, shows anti-cancer and anti-metastatic effects in colon cancer and tumoroids (Hela cell IC50=455 nM). |
| PC-24239 |
IMB5046
Microtubule inhibitor
|
IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo. |
| PC-24204 |
TUBG1 inhibitor L12
γ-tubulin1 inhibitor
|
TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2. |
| PC-24203 |
Citral dimethyl acetal
γ-tubulin inhibitor
|
Citral dimethyl acetal (CDA) is a specific inhibitor of γ-tubulin, specifically inhibits the nuclear activity of γ-tubulin without affecting microtubules dynamics, increases E2F activity without affecting microtubules. |
| PC-24202 |
Citral
γ-tubulin inhibitor
|
Citral is a natural ALDH1A inhibitor, also is a small molecule inhibitor of nuclear γ-tubulin, affects the transcriptional activity of E2F and the protein levels of RB1. |
| PC-23753 |
C118P
Microtubule inhibitor
|
C118P is a phosphate prodrug of C118, which is a novel microtubule protein inhibitor, exhibits good inhibitory activities against ovarian cancer and lung cancer. |
