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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-Cevipabulin
Cevipabulin

Chemical Structure : Cevipabulin

CAS No.: 849550-05-6

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Cevipabulin (TTI-237, TTI 237)

货号: PC-25976Not For Human Use, Lab Use Only.

Cevipabulin (TTI-237) is a microtubule-stabilizing agent by binding to the vinblastine site, also binds to a new site on α-tubulin, shows IC50 of 18-40 nM for cytotoxicity in a panel of human tumor cell lines.

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50 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cevipabulin (TTI-237) is a microtubule-stabilizing agent by binding to the vinblastine site, also binds to a new site on α-tubulin, shows IC50 of 18-40 nM for cytotoxicity in a panel of human tumor cell lines.

物理化学性质&存储条件

分子量 464.83
分子式 C18H18ClF5N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-Chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

参考文献

1. Nasrin SR, et al. Biochem Biophys Res Commun. 2019 Aug 27;516(3):760-764.

2. Kovalevich J, et al. J Pharmacol Exp Ther. 2016 May;357(2):432-50.

3. Yang J, et al. Sci Adv. 2021 May 19;7(21):eabg4168.

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