OXi6196 | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : OXi6196

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OXi6196 (Oxi-6196)

货号: PC-25512Not For Human Use, Lab Use Only.

OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay.

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生物&药学活性

OXi6196 is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization utilizing a cell-free assay.
OXi6196 shows cytotoxicity in the low nM range (IC50 2.2–4.5 nM) in human SK-OV-3 ovarian, DU-145 prostate, NCI-H460 lung cells and murine hemangioendothelioma MHEC-5T cancer cells.
OXi6196 caused G2/M cell cycle arrest.
OXi6196 (100 nM) disrupted capillary-like endothelial networks pre-established with HUVECs on Matrigel®.

物理化学性质&存储条件

分子量	342.39
分子式	C20H22O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methoxy-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphthalen-1-ol

参考文献

1. Liu L, et al. Cancers (Basel). 2022 Aug 30;14(17):4208.

2. Maguire C.J, et al. Medchemcomm. 2018;9:1649–1662.

OXi6196 (Oxi-6196)

生物&药学活性

物理化学性质&存储条件

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OXi6196 (Oxi-6196)

生物&药学活性

物理化学性质&存储条件

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