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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-OXi6197
OXi6197

Chemical Structure : OXi6197

CAS No.: 666712-68-1

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OXi6197 (KGP04)

货号: PC-25513Not For Human Use, Lab Use Only.

OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

OXi6197 (KGP04) is the phosphate prodrug of OXi6196, which is a potent tubulin-binding agent with IC50 of 200 nM for inhibition of tubulin polymerization, rapidly releases OXi6196 in the presence of alkaline phosphatase.
OXi6197 (25 to 100 mg/kg daily for 5 days, i.p.) significantly inhibited growth of MDA-MB-231 in mice.
OXi6197causees vascular disruption and tumor growth delay in vivo based on orthotopic human MDA-MB-231 human breast tumor xenografts in NOD SCID mice and orthotopic RENCA kidney tumors in syngeneic BALB/C mice.

物理化学性质&存储条件

分子量 466.33
分子式 C20H21Na2O8P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 2-methoxy-5-(3,4,5-trimethoxyphenyl)-7,8-dihydronaphthalen-1-yl phosphate

参考文献

1. Liu L, et al. Cancers (Basel). 2022 Aug 30;14(17):4208.

2. Maguire C.J, et al. Medchemcomm. 2018;9:1649–1662.

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