KGP265

Chemical Structure : KGP265

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货号: PC-25514Not For Human Use, Lab Use Only.

KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18.

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生物&药学活性

KGP265 is a water-soluble phosphate prodrug salt of benzosuberene-based tubulin-binding agent KGP18.
KGP265 exhibits cytotoxicity against human cancer cell lines SK-OV-3, NCI-H460, and DU-145 with IC50 of <10 nM.
KGP265 caused significant growth delay in both MDA-MB-231 and 4T1 breast tumors, with no obvious systemic toxicity.

物理化学性质&存储条件

分子量	480.36
分子式	C21H23Na2O8P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-yl phosphate

参考文献

1. Yihang Guo, et al. Cancers (Basel). 2021 Sep 24;13(19):4769.

2. Tanpure R.P., et al. Bioorg. Med. Chem. Lett. 2013;21:8019–8032.

KGP265

生物&药学活性

物理化学性质&存储条件

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KGP265

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