| Cat. No. |
Product Name |
Information |
| PC-28673 |
DCPR049-12
Type I PRMTs inhibitor
|
DCPR049_12 (DCPR049-12) is a potent, selective inhibitor of type I PRMTs with IC50 of 1.1 nM (PRMT1), 22 nM (PRMT3), 63 nM (PRMT4), 1.2 nM (PRMT6) and 1.8 nM (PRMT8), does not inhibit PRMT5. |
| PC-28672 |
ZL-28-6
CARM1 inhibitor
|
ZL-28-6 is a potent, selective inhibitor of CARM1 (coactivator-associated arginine methyltransferase 1, PRMT4) with IC50 of 18 nM, inhibits CARM1 and PRMT1 at a similar level. |
| PC-28671 |
WCJ-394
PRMT1 inhibitor
|
WCJ-394 is a potent PRMT1 inhibitor with IC50 of 1.21 uM, exhibits similar inhibitory activities against PRMT4 and PRMT8, weakly inhibits PRMT3 and PRMT6. |
| PC-28664 |
CBX2 inhibitor 16
CBX2 inhibitor
|
CBX2 inhibitor 16 is a potent, small molecule CBX2 inhibitor with IC50 of 14.4 uM in NanoBiT assays. |
| PC-28652 |
CM-579 trihydrochloride
G9a/DNMTs inhibitor
|
CM-579 trihydrochloride (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively. |
| PC-28195 |
MM-401 TFA
MLL1/WDR5 inhibitor
|
MM-401 TFA is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM. |
| PC-28194 |
MS2928 TFA
SETD8 inhibitor
|
MS2928 TFA is a potent and selective SETD8 covalent inhibitor, inhibits SETD8 methyltransferase activity with IC50 of 0.14 uM, covalently modifies SETD8 at Cys311. |
| PC-28193 |
ND-L11B TFA
NSD2 degrader
|
ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells. |
| PC-28192 |
GSK2807 Trifluoroacetate
SMYD3 inhibitor
|
GSK2807 Trifluoroacetate (GSK 2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM and IC50 of 130 nM. |
| PC-27907 |
AN-465 dihydrochloride
EV71 inhibitor, METTL3 inhibitor
|
AN-465 dihydrochloride (AN-465/42162872, AN465) is a potent inhibitor of Enterovirus 71 (EV71) with EC50 of 18.48 uM, effectively inhibits m6A methyltransferase METTL3 with IC50 of 1.782 uM and KD of 8.75 uM. |
| PC-27334 |
IGF2BP3-IN-2
IGF2BP3 inhibitor
|
IGF2BP3-IN-2 is a potent, selective small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) with IC50 of 0.12 uM in cellular thermal shift assay (CETSA). |
| PC-26565 |
GD433
NTMT1 inhibitor
|
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM. |
