| Cat. No. |
Product Name |
Information |
| PC-22335 |
iCARM1
CARM1 inhibitor
|
iCARM1 (ZINC65534584) is a potent, selective inhibitor of protein arginine methyltransferase CARM1 (PRMT4) with IC50 of 12.3 uM, Biacore Kd of 0.67 uM. |
| PC-22135 |
AMG 193
PRMT5 inhibitor
|
Anvumetostat (AMG 193, AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM). |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
Vopimetostat (TNG462, TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (Ralometostat, TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
| PC-22053 |
MS8535
SPIN1 inhibitor
|
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM. |
| PC-21974 |
Bleximenib oxalate
menin-KMT2A inhibitor
|
Bleximenib oxalate (JNJ-75276617 oxalate) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
| PC-21973 |
JNJ-75276617
menin-KMT2A inhibitor
|
JNJ-75276617 (Bleximenib) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
| PC-21950 |
GSK343
EZH2 inhibitor
|
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM. |
| PC-21938 |
Tazemetostat
EZH2 inhibitor
|
Tazemetostat (EPZ-6438) is a potent, selective, SMA-competitive and orally available EZH2 inhibitor with IC50 of 11 and 16 nM in peptide assay and nucleosome assay, respectively. |
| PC-21857 |
BI-9321 trihydrochloride
NSD3 inhibitor
|
BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-21842 |
GSK3368715 dihydrochloride
Type 1 PRMT inhibitor
|
GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8. |
| PC-21619 |
EPZ004777
DOT1L inhibitor
|
EPZ004777 is a potent, selective inhibitor of DOT1L with Ki of 0.3 nM and IC50 of 0.4 nM, selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. |
