| Cat. No. |
Product Name |
Information |
| PC-22670 |
Thiol methyltransferase inhibitor DCMB
METTL7A inhibitor
|
Thiol methyltransferase inhibitor DCMB is a small moelcule inhibitor of thiol methyltransferase (TMT) with IC50 of 1.17 uM for METTL7A (TMT1A). |
| PC-22471 |
DC-Y13-27
YTHDF2 inhibitor
|
DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay. |
| PC-22438 |
DF-A7
YTHDF2 inhibitor
|
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3. |
| PC-22432 |
MS152
EHMT2/G9a inhibitor
|
MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively. |
| PC-22335 |
iCARM1
CARM1 inhibitor
|
iCARM1 (ZINC65534584) is a potent, selective inhibitor of protein arginine methyltransferase CARM1 (PRMT4) with IC50 of 12.3 uM, Biacore Kd of 0.67 uM. |
| PC-22135 |
AMG 193
PRMT5 inhibitor
|
Anvumetostat (AMG 193, AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM). |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
Vopimetostat (TNG462, TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (Ralometostat, TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
| PC-22119 |
ORIC-944
PRC2 EED inhibitor
|
ORIC-944 (Rinzimetostat) is a potent, selective, allosteric and orally bioavailable PRC2 inhibitor with EED binding EC50 of 106 pM and biochemical PRC2 EC50 of 16.7 nM. |
| PC-22053 |
MS8535
SPIN1 inhibitor
|
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM. |
| PC-21974 |
Bleximenib oxalate
menin-KMT2A inhibitor
|
Bleximenib oxalate (JNJ-75276617 oxalate) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
| PC-21973 |
JNJ-75276617
menin-KMT2A inhibitor
|
JNJ-75276617 (Bleximenib) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
