| Cat. No. |
Product Name |
Information |
| PC-23344 |
BR0063
PRC2 inhibitor
|
BR0063 is a potent, selective EED-directed allosteric inhibitor of polycomb repressive complex 2 (PRC2), efficiently blocks the interaction of the EED subunit with H3K27me3 (EC50=5.9 nM), which led to the marked inhibition of cellular PRC2 activity. |
| PC-23238 |
YD1342
PRMT4 inhibitor
|
YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM). |
| PC-23237 |
YD1130
PRMT4 inhibitor
|
YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs. |
| PC-23204 |
SETD8 inhibitor C23
SETD8 inhibitor
|
SETD8 inhibitor C23 is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci. |
| PC-23098 |
Igermetostat
EZH2 inhibitor
|
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2. |
| PC-23079 |
MS167
PRMT6 inhibitor
|
MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM. |
| PC-23078 |
MS117
PRMT6 inhibitor
|
MS117 is a potent, selective and cell-active covalent PRMT6 inhibitor with Ki of 16 nM and IC50 of 18 nM. |
| PC-22924 |
EML425
CBP/p300 inhibitor
|
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively. |
| PC-22923 |
MS3745
G9a-like protein inhibitor
|
MS3745 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 4 nM, 65-fold selective over G9a. |
| PC-22922 |
MS3748
G9a-like protein inhibitor
|
MS3748 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 5 nM, 59-fold selective over G9a. |
| PC-22921 |
EML741
G9a/GLP inhibitor
|
EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays. |
| PC-22846 |
CDYL inhibitor Compound D03
CDYL inhibitor
|
Compound D03 is a potent and selective small-molecule inhibitor of histone methyllysine reader protein chromodomain Y-like (CDYL) with SPR KD of 0.5 uM, disrupts the recruitment of CDYL onto chromatin. |
