| Cat. No. |
Product Name |
Information |
| PC-63135 |
MS0124
G9a-like protein inhibitor
|
MS-0124 is a potent and selective inhibitor of G9a-like Protein (GLP) lysine methyltransferase with IC50 of 13 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases.. |
| PC-63022 |
G9a inhibitor E72
G9a/GLP inhibitor
|
G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2. |
| PC-62981 |
CMP-5
PRMT5 inhibitor
|
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
| PC-62980 |
CMP-5 hydrochloride
PRMT5 inhibitor
|
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
| PC-62758 |
Chaetocin
SUV39H1 inhibitor
|
Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 (SUV39H1) with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9. |
| PC-62736 |
CN-SAH
DOT1L inhibitor
|
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.. |
| PC-62527 |
PF-06726304
EZH2 inhibitor
|
PF-06726304 is a novel potent enhancer of zeste homolog 2 (EZH2) inhibitor with IC50 of <5 nM, Ki of 0.7/3.0 nM (Wt/Y641N). |
| PC-62526 |
EBI-2511
EZH2 inhibitor
|
EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G. |
| PC-62486 |
M-525
Menin-MLL inhibitor
|
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays. |
| PC-62485 |
MI-2-2
Menin-MLL inhibitor
|
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
| PC-62484 |
MI-2-2 hydrochloride
menin-MLL inhibitor
|
MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
| PC-62468 |
EZH2-IN-3
EZH2 inhibitor
|
EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively. |
