| Cat. No. |
Product Name |
Information |
| PC-26996 |
TNG917
EHMT1/2 inhibitor
|
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases. |
| PC-26788 |
AZD3470
PRMT5 inhibitor
|
AZD3470 (AZD-3470) is a potent, seleective MTA-cooperative PRMT5 inhibitor, targets MTAP deficient advanced/metastatic cancer cells. |
| PC-26595 |
SCR-6920
PRMT5 inhibitor
|
SCR-6920 is a potent and selective, oral PRMT5 inhibitor with IC50 of 1.48 nM. |
| PC-26591 |
NSUN2 inhibitor AK
NSUN2 inhibitor
|
NSUN2 inhibitor AK (AK-968/36977265) is a small molecule inhibitor of RNA methyltransferase NSUN2, decreases m5C occupancy and GATM mRNA levels, shows anti-fibrotic efficacy. |
| PC-26589 |
UNC7242
PHF1/PHF19 inhibitor
|
UNC7242 is a small molecule antagonist of PRC2 components PHF1 and PHF19 with ITC Kd of 1.13 uM and 0.64 uM, displaces recombinant or endogenous PHF1 or 19 from nucleosomes. |
| PC-26565 |
GD433
NTMT1 inhibitor
|
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM. |
| PC-26542 |
EP102
METTL3 inhibitor
|
EP102 is a potent, selective METTL3 inhibitor with IC50 of 2 nM in SPA primary assay. |
| PC-26532 |
METTL16-IN-1
METTL16 inhibitor
|
METTL16-IN-1 is a specific small molecule METTL16 inhibitor with IC50 of 1.7 uM against the METTL16-RNA binding. |
| PC-26383 |
(+)SHIN2
SHMT1/2 inhibitor
|
(+)SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
| PC-26366 |
WDR5 oligomerization inducer WZ-1
WDR5 oligomerization inducer
|
WZ-1 is a selective WDR5 oligomerization inducer, binds the WBM site of WDR5 and reacts with Cys248 to form an intramolecular disulfide, triggers oligomerization via thio-disulfide exchange, disrupting WDR5 interactions at both WIN and WBM sites. |
| PC-26274 |
SGSS05NS
SETD8 inhibitor
|
SGSS05NS is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 0.54 uM, covalently modifies SETD8 at Cys311. |
| PC-26273 |
MS4138
SETD8 inhibitor
|
MS4138 is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 1.4 uM, covalently modifies SETD8 at Cys311. |
