Nsun2-i4 | NSUN2 inhibitor | Probechem Biochemicals

Chemical Structure : Nsun2-i4

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Nsun2-i4 (NSUN2 inhibitor i4)

货号: PC-24232Not For Human Use, Lab Use Only.

Nsun2-i4 is a specific small molecule inhibitor of m5C methyltransferase NSUN2 with KD of 2.65 uM in MST assays.

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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Nsun2-i4 is a specific small molecule inhibitor of m5C methyltransferase NSUN2 with KD of 2.65 uM in MST assays.
Nsun2-i4 exhibits inhibitory effects in CRC cell lines with the lowest IC50 values measured at 56.04 µM in SW480 cell and 45.79 µM in HT29 cell, respectively.
Nsun2-i4 (50 uM, 12h) decreased the expression levels of ENO1 and GRB2 proteins in treating CRC cells.
Nsun2-i4 (50 mg/kg intraperitoneally) effectively inhibited tumor growth rates and reduced the total tumor burden in AOM/DSS‐induced CRC
Nsun2-i4 does not result in any significant changes in body weight, or the histopathological analyses of major organs, including the kidney, liver, spleen, and colon.
Nsun2-i4 treatment caused significant cGAMP‐induced activation of p‐STING and p‐TBK1 in CRC cells.
Nsun2-i4 demonstrated a significantly enhanced inhibitory effect on tumor growth when combined with PD‐1.

物理化学性质&存储条件

分子量	453.51
分子式	C23H23N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-cyano-4-(3-ethoxy-4-hydroxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(4-methoxyphenyl)acetamide

参考文献

1. Chen B, et al. Adv Sci (Weinh). 2024 Jul;11(28):e2309840.

2. Hou X, et al. Theranostics. 2025 Jan 27;15(7):2757-2777.

Nsun2-i4 (NSUN2 inhibitor i4)

生物&药学活性

物理化学性质&存储条件

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Nsun2-i4 (NSUN2 inhibitor i4)

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物理化学性质&存储条件

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