ZL-28-6

Chemical Structure : ZL-28-6

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货号: PC-28672Not For Human Use, Lab Use Only.

ZL-28-6 is a potent, selective inhibitor of CARM1 (coactivator-associated arginine methyltransferase 1, PRMT4) with IC50 of 18 nM, inhibits CARM1 and PRMT1 at a similar level.

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生物&药学活性

ZL-28-6 is a potent, selective inhibitor of CARM1 (coactivator-associated arginine methyltransferase 1, PRMT4) with IC50 of 18 nM, inhibits CARM1 and PRMT1 at a similar level.
ZL-28-6 inhibits PABP1me2a, BAF155me2a, and ADMA levels in SKHep1 and MCF7 cells.
ZL-28-6 has broad spectrum of anticancer activity toward a series of solid tumor cells.

物理化学性质&存储条件

分子量	353.29
分子式	C18H22Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(2-((2,3-dichlorobenzyl)oxy)benzyl)-N1,N2-dimethylethane-1,2-diamine

参考文献

1. Li X, et al. J Chem Inf Model. 2022 Feb 14;62(3):692-702.

ZL-28-6

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ZL-28-6

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