| Cat. No. |
Product Name |
Information |
| PC-20238 |
RGFP963
HDAC3 inhibitor
|
RGFP963 (RGFP 963) is a potent, selective class I HDAC inhibitor with IC50 of 1.51 uM, 0.75 and 0.096 uM for HDAC1, HDAC2, and HDAC3, respectively. |
| PC-20237 |
RGFP966
HDAC3 inhibitor
|
RGFP966 (RGFP 966) is a potent, specific HDAC3 inhibitor with IC50 of 0.08 uM, without effective inhibition of any other HDACs at 15 uM. |
| PC-20197 |
TTA03-107
HDAC1 inhibitor
|
TTA03-107 is a potent, selective HDAC1 inhibitor with Ki of 3.22 and 17.6 nM for HDAC1/2, respectively. |
| PC-20141 |
HDAC10 inhibitor 10c
HDAC10 inhibitor
|
HDAC10 inhibitor 10c is a potent, selective HDAC10 inhibitor with IC50 of 20 nM, shows high specificity over HDAC6 and with no significant impact on class I HDACs. |
| PC-49844 |
NBM-T-L-BMX-OS01
HDAC8 inhibitor
|
NBM-T-L-BMX-OS01 (BMX, HDAC8 inhibitor) is a potent, selective and BB penetrant HDAC8 inhibitor with IC50 of 831 nM. |
| PC-49678 |
YSL-109
HDAC6 inhibitor
|
YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8. |
| PC-49539 |
GH8HA01
HDAC8 inhibitor
|
GH8HA01 is a highly potent, selective HDAC8 inhibitor with Ki of 0.67 nM, highly selective against HDAC8 compared to other HDACs. |
| PC-49452 |
NN-429
HDAC6 inhibitor
|
NN-429 (NN429) is a potent, selective second-generation inhibitor of HDAC6 with IC50 of 3.2 nM, >312-fold selectivityt over all HDAC isoforms. |
| PC-49363 |
DKFZ-748
HDAC10 inhibitor
|
DKFZ-748 (DKFZ748) is a potent, specific HDAC10 inhibitor with cellular IC50 of 22 nM, >500-fold selectivity over other HDAC isozymes. |
| PC-49250 |
TYA-018
HDAC6 inhibitor
|
TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). |
| PC-49104 |
MPT0B390
HDAC1/2 inhibitor
|
MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells. |
| PC-49072 |
KH-259
HDAC6 inhibitor
|
KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM). |
