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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Bavarostat
Bavarostat

Chemical Structure : Bavarostat

CAS No.: 2134109-20-7

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Bavarostat (EKZ-001)

货号: PC-24769Not For Human Use, Lab Use Only.

Bavarostat (EKZ-001) is a potent, selective HDAC6 inhibitor with IC50 of 60 nM, 16000-fold selectivity over HDAC1, HDAC2, and HDAC3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bavarostat (EKZ-001) is a potent, selective HDAC6 inhibitor with IC50 of 60 nM, 16000-fold selectivity over HDAC1, HDAC2, and HDAC3.
Bavarostat is used as a brain-penetrant positron emission tomography (PET) probe for imaging HDAC6 in the central nervous system.

物理化学性质&存储条件

分子量 346.45
分子式 C20H27FN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(((Adamantan-1-ylmethyl)(methyl)amino)methyl)-3-fluoro-N-hydroxybenzamide

参考文献

1. Wagner FF, et al. ACS Cent Sci. 2017 Sep 27;3(9):1006-1014.

2. Porter NJ, et al. J Med Chem. 2018 Sep 13;61(17):8054-8060.

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