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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-ITF3756
ITF3756

Chemical Structure : ITF3756

CAS No.: 2247608-27-9

ITF3756 (ITF-3756)

货号: PC-24773Not For Human Use, Lab Use Only.

ITF3756 (ITF-3756) is a potent, selective HDAC6 inhibitor with IC50 of 17 nM, >80-fold selective versus HDAC8 and HDAC Class IIa isoforms (HDAC4, 5, 7, and 9).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ITF3756 (ITF-3756) is a potent, selective HDAC6 inhibitor with IC50 of 17 nM, >80-fold selective versus HDAC8 and HDAC Class IIa isoforms (HDAC4, 5, 7, and 9).

物理化学性质&存储条件

分子量 301.32
分子式 C13H11N5O2S:
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, N-hydroxy-4-[[5-(2-thienyl)-1H-tetrazol-1-yl]methyl]-

参考文献

1. Sandrone G, et al. ACS Med Chem Lett. 2021 Oct 11;12(11):1810-1817.

2. Zamperla MG, et al. Clin Epigenetics. 2024 Aug 18;16(1):109.

3. Barbara Vergani, et al. J Med Chem. 2019 Dec 12;62(23):10711-10739.

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