| Cat. No. |
Product Name |
Information |
| PC-26795 |
W2A-28
class I HDAC inhibitor, Wnt/β-catenin activator
|
W2A-28 is a dual modulator of class I HDACs and Wnt/β-catenin signaling, inhibits HDAC1, 2 and 3 with IC50 of 0.51 μM, 0.68 μM and 0.22 μM, respectively, activates Wnt/β-catenin signaling with EC50 of 1.61 μM in Wnt-3A-expressing HEK293 cells. |
| PC-26710 |
SP108
HDAC3 inhibitor
|
SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively. |
| PC-26518 |
3-Cl BA
HDAC inhibitor
|
3-Cl BA is a potent HDAC inhibitor, significantly enhances epithelial barrier formation and wound healing in vitro. |
| PC-26486 |
GV-001
HDAC6 inhibitor
|
GV-001 is a potent, selective and orally bioavailable HDAC6 inhibitor with IC50 of 1.18 nM, shows >200- and 1900-fold selectivity over HDAC1 and HDAC8. |
| PC-26373 |
CDC1011
UCP1 activator, HDAC inhibitor
|
CDC1011 is a small molecule uncoupling protein 1 (UCP1) activator, significantly upregulates the transcriptional expression of UCP1 in differentiated SW872 adipocytes, functions as an HDAC inhibitor. |
| PC-26251 |
AMC-3-030
HDAC/proteasome inhibitor
|
AMC-3-030 is a potent, dual HDAC6/proteasome inhibitor with IC50 of 884 nM for HDAC6 and IC50 of 4.17 nM in cell-free 20S proteasomal chymotrypsin-like activity assay. |
| PC-26231 |
Scriptaid
HDAC inhibitor
|
Scriptaid (Scriptide, GCK1026) is a potent small molecule histone deacetylase (HDAC) inhibitor. |
| PC-26230 |
Pyroxamide
HDAC inhibitor
|
Pyroxamide is a potent inhibitor of HDAC with IC50 of 100 nM for HDAC1, causes the accumulation of acetylated core histones in murine erythroleukemia (MEL) cells. |
| PC-26229 |
VS-186B
HDAC inhibitor
|
VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner. |
| PC-26064 |
UVI5008
Epigenetic inhibitor
|
UVI5008 is a small molecule epigenetic modifier/modulator that inhibits histone deacetylases, sirtuins, and DNA methyltransferases, affects the death receptor (DR) pathway and reactive oxygen species (ROS) production in cancer cells. |
| PC-25935 |
Colrestat
class I HDAC inhibitor
|
Colrestat is a potent, selective inhibitor of class I histone deacetylases (HDACs) with IC50 of 41.2 nM, 52.5 nM and 74.3 nM for HDAC1, HDAC2 and HDAC3 respectively. |
| PC-25904 |
Mesinostat
HDAC6 inhibitor
|
Mesinostat is a potent and selective HDAC6 inhibitor with IC50 of 7.7 nM, >200-fold selective over HDAC1. |
