| Cat. No. |
Product Name |
Information |
| PC-27904 |
USP15 inhibitor Z86
USP15 inhibitor, Wnt inhibitor
|
USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4. |
| PC-26833 |
SGC-UBD1031
USP16/HDAC6-UBD inhibitor
|
SGC-UBD1031 (UBD1031) is a potent, specific dual USP16 and HDAC6 zinc-finger ubiquitin-binding domain (UBD) with SPR Kd of 48 nM and 16 nM respectively, disrupts the interaction between the C-terminus of ISG15 and USP16-UBD, as well as the interaction between ISG15 and HDAC6-UBD with IC50 of 1.7 uM and 1.5 uM in cellular assays. |
| PC-26806 |
NK192
USP7 inhibitor
|
NK192 is a potent, selective USP7 inhibitor with IC50 of 20 nM, shows proteome-wide specificity. |
| PC-26791 |
ZHAWOC8655
USP18 inhibitor
|
ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15. |
| PC-26670 |
Berberine chloride
USP22 inhibitor
|
Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation. |
| PC-26656 |
Berberine chloride hydrate
USP22 inhibitor
|
Berberine chloride hydrate (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, disrupts G-quadruplex (G4)-STAT1 interaction and synergizes with olaparib to drive cancer cell death, shows antineoplastic properties, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation. |
| PC-26479 |
P6620
USP7 inhibitor
|
P6620 is a specific small molecule inhibitor USP7, effectively inhibits the USP7/LRRC41 axis to suppress HCC malignancy. |
| PC-26236 |
USP11 inhibitor 26
USP11 inhibitor
|
USP11 inhibitor 26 (USP11-IN-1) is a selective inhibitor of USP11 with IC50 of 10.9 uM, shows 1.7- and >100-fold selective over USP4 and USP15. |
| PC-26235 |
USP11 inhibitor 7
USP11 inhibitor
|
USP11 inhibitor 7 (USP11-IN-2) is a selective inhibitor of USP11 with IC50 of 2.6 uM, shows >30- and 100-fold selective over USP4 and USP15. |
| PC-26201 |
WWQ-03-012
DESI2 inhibitor
|
WWQ-03-012 is a potent, specific and covalent inhibitor of JAK2‐V617F complex component DESI2 with IC50 of 47.3 nM, selectively degrades mutant JAK2. |
| PC-25571 |
OAT-4828 dihydrochloride
USP7 inhibitor
|
OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25550 |
USP19-IN-1
USP19 inhibitor
|
USP19-IN-1 (Example 124) is a potent, selective USP19 inhibitor with IC50 of <0.5 uM, high selective against a panel of 24 USPs and 19 other DUBs. |
