| Cat. No. |
Product Name |
Information |
| PC-45341 |
ML323
USP1 inhibitor
|
ML323 (ML 323) is a potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM. |
| PC-42288 |
ML364
USP2 inhibitor
|
ML364 is a potent, selective and reversible ubiquitin-specific protease USP2 inhibitor with IC50 of 1.1 uM. |
| PC-43555 |
P50429
USP7/USP47 inhibitor
|
P50429 (P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs. |
| PC-45339 |
HBX 19818
USP7 inhibitor
|
HBX 19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM. |
| PC-45856 |
USP8-IN-22d
USP8 inhibitor
|
USP8-IN-22d is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM. |
| PC-45857 |
USP8-IN-22c
USP8 inhibitor
|
USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM. |
| PC-45056 |
USP7-IN-1
USP7 inhibitor
|
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM. |
| PC-46007 |
SJB3-019A
USP1 inhibitor
|
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. |
| PC-28630 |
USP5-IN-2
USP5 inhibitor
|
USP5-IN-2 (Compound 25) is a highly selective small molecule inhibitor of deubiquitinating enzyme USP5 with IC50 of 39.15 uM, does not inhibit USP18 or any other detected deISGylases, reduces SARS-CoV-2 replication, also shows antiviral activity against influenza A virus and encephalomyocarditis virus with IC50 of ~1.9 µM and ~5.1 µM, respectively |
| PC-28629 |
USP47-IN-1
USP47 inhibitor
|
USP47-IN-1 (Compound 3) is a specific small molecule inhibitor of deubiquitinating enzyme USP47 with IC50 of 0.46 uM, shows 10-fold selectivity over USP7, covalently binds at the thumb-palm cleft and sterically blocks Ub binding. |
| PC-28628 |
OTUD7B-IN-1
OTUD7B inhibitor
|
OTUD7B-IN-1 (Compound 6) is a specific small molecule inhibitor of eubiquitinating enzyme OTUD7B, inhibits recombinant catalytic domain of OTUD7B with IC50 of 1.9 uM, dose not inhibit USP16 and USP28. |
| PC-27978 |
Hemi-ubistatin
Ubiquitin-proteasome system inhibitor
|
Hemi-ubistatin B (h-ubiB) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, penetrates cancer cells and alters the cellular ubiquitin landscape. |
