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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-Hemi-ubistatin
Hemi-ubistatin

Chemical Structure : Hemi-ubistatin

CAS No.:

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Hemi-ubistatin (h-ubiB)

货号: PC-27978Not For Human Use, Lab Use Only.

Hemi-ubistatin B (h-ubiB) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, penetrates cancer cells and alters the cellular ubiquitin landscape.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Hemi-ubistatin B (h-ubiB) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, penetrates cancer cells and alters the cellular ubiquitin landscape.

物理化学性质&存储条件

分子量 449.36
分子式 C16H9N3Na2O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium 2-(3-sulfonatophenyl)-2H-naphtho[1,2-d][1,2,3]triazole-7-sulfonate

参考文献

1. Verma R, et al. Science. 2004 Oct 1;306(5693):117-20.

2. Nakasone MA, et al. Structure. 2017 Dec 5;25(12):1839-1855.e11.

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