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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-USP5-IN-2
USP5-IN-2

Chemical Structure : USP5-IN-2

CAS No.:

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USP5-IN-2

货号: PC-28630Not For Human Use, Lab Use Only.

USP5-IN-2 (Compound 25) is a highly selective small molecule inhibitor of deubiquitinating enzyme USP5 with IC50 of 39.15 uM, does not inhibit USP18 or any other detected deISGylases, reduces SARS-CoV-2 replication, also shows antiviral activity against influenza A virus and encephalomyocarditis virus with IC50 of ~1.9 µM and ~5.1 µM, respectively

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

USP5-IN-2 (Compound 25) is a highly selective small molecule inhibitor of deubiquitinating enzyme USP5 with IC50 of 39.15 uM, does not inhibit USP18 or any other detected deISGylases, reduces SARS-CoV-2 replication, also shows antiviral activity against influenza A virus and encephalomyocarditis virus with IC50 of ~1.9 µM and ~5.1 µM, respectively

物理化学性质&存储条件

分子量 431.96
分子式 C19H34ClN5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-((S)-2-acetamido-4-methylpentanamido)-6-amino-N-(2-oxo-2-(prop-2-yn-1-ylamino)ethyl)hexanamide hydrochloride

参考文献

1. Jones HBL, et al. NPJ Drug Discov. 2026 Oct 26;3(1):52.

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