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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-USP47-IN-1
USP47-IN-1

Chemical Structure : USP47-IN-1

CAS No.:

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USP47-IN-1

货号: PC-28629Not For Human Use, Lab Use Only.

USP47-IN-1 (Compound 3) is a specific small molecule inhibitor of deubiquitinating enzyme USP47 with IC50 of 0.46 uM, shows 10-fold selectivity over USP7, covalently binds at the thumb-palm cleft and sterically blocks Ub binding.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

USP47-IN-1 (Compound 3) is a specific small molecule inhibitor of deubiquitinating enzyme USP47 with IC50 of 0.46 uM, shows 10-fold selectivity over USP7, covalently binds at the thumb-palm cleft and sterically blocks Ub binding.

物理化学性质&存储条件

分子量 292.33
分子式 C19H16O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1(C(C2=CC=CC=C2)O1)CC3)C3(O4)C4C5=CC=CC=C5

参考文献

1. Jones HBL, et al. NPJ Drug Discov. 2026 Oct 26;3(1):52.

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