USP15 inhibitor Z86

Chemical Structure : USP15 inhibitor Z86

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货号: PC-27904Not For Human Use, Lab Use Only.

USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4.
Z86 also is a Wnt signaling inhibitor, selectively inhibits the growth of CRC cells with constitutive Wnt signaling and caused obvious G1-phase arrest of the cell cycle.
Z86 inhibits GSK3β (Ser9) phosphorylation, leading to its overactivation and promoting the phosphorylation and degradation of β-catenin.
Z86 is also a novel PI3Kα inhibitor with potent inhibitory efficiency on PI3K-mediated CRCs growth and migration.

物理化学性质&存储条件

分子量	408.50
分子式	C27H24N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl 9-ethyl-1- (naphthalen-1-yl)-9H-pyrido[3,4-b]indole-3- carboxylate

参考文献

1. Li X, et al. Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling. Cell Death Discov. 2015;1:15033.

2. Nie S, et al. beta-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. Nat Prod Bioprospect. 2024;14(1):3.

3. Wang Y, et al. Nat Prod Bioprospect. 2026 Aug 28;16(1):84.