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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-Berberine chloride
Berberine chloride

Chemical Structure : Berberine chloride

CAS No.: 633-65-8

Berberine chloride

货号: PC-26670Not For Human Use, Lab Use Only.

Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Berberine chloride is an alkaloid with antibiotic properties, induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase, also directly binds to transcription factor Early B Cell Factor 2 (EBF2), modulate EBF2 phase separation and thermogenic function, also is a potent USP22 inhibitor, effectively suppresses Wnt pathway activation and CRC cell proliferation.

物理化学性质&存储条件

分子量 371.82
分子式 C20H18ClNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride

参考文献

1. Wang X, et al. Nat Commun. 2026 Apr 23. doi: 10.1038/s41467-026-72233-x.

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