OAT-4828 dihydrochloride

Chemical Structure : OAT-4828 dihydrochloride

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货号: PC-25571Not For Human Use, Lab Use Only.

OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system).
OAT-4828 shows high selectivity against other deubiquitinases at 10 uM.
OAT-4828 inhibits the Wnt/β-catenin pathway with EC50 at 0.15 uM in human CRC cells of the SW480 cell line.
OAT-4828 prolongs survival of B16F10-bearing mice and boosts T-cell antitumor activity.
OAT-4828 reshapes the tumor microenvironment and promotes the antitumor function of myeloid cell subpopulations.
T Cells are crucial for OAT-4828 antitumor activity, which can be further improved by anti-PD-1 treatment.
OAT-4828 activates human T cells by increasing NFATC2 activity and MDM2 downregulation.

物理化学性质&存储条件

分子量	644.54
分子式	C28H30Cl2F3N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Azabicyclo[3.1.0]hexane-2,4-dione, 6,6-dimethyl-3-[[7-[4-methyl-3-[[(3S)-3-(methylamino)-1-pyrrolidinyl]carbonyl]-6-(trifluoromethyl)-2-pyridinyl]thieno[3,2-b]pyridin-2-yl]methyl]-, hydrochloride (1:2)

参考文献

1. Muchowicz A, et al. J Immunother Cancer. 2025 Sep 25;13(9):e012287.