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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-ZHAWOC8655
ZHAWOC8655

Chemical Structure : ZHAWOC8655

CAS No.: 1257657-02-5

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ZHAWOC8655

货号: PC-26791Not For Human Use, Lab Use Only.

ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZHAWOC8655 is a small molecule USP18 inhibitor with IC50 of 14.1 uM (hUSP18), disrupts the intracellular binding of USP18/ISG15.

物理化学性质&存储条件

分子量 356.43
分子式 C22H20N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8-Methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5-phenyl-1H-pyrazol-3-yl)methanone

参考文献

1. Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.

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