| Cat. No. |
Product Name |
Information |
| PC-28215 |
EVT-401
P2X7R antagonist
|
EVT-401 (EVT401) is a potent, highly selective human P2X7 receptor (P2X7R) antagonist with Ki of 7.6 nM in competitive binding assays. |
| PC-27099 |
P2X7R antagonist A20
P2X7 antagonist
|
P2X7R antagonist A20 (Compound 9q) is a potent, selective antagonist of ATP-gated channel P2X7 receptor (P2X7R) with IC50 of 18 nM (hP2X7), exhibits non-competitive negative allosteric mode of antagonism. |
| PC-26954 |
(Rac)-EVT-401
P2X7R antagonist
|
(Rac)-EVT-401 is the racemate form of EVT-401, a potent, highly selective human P2X7 receptor (P2X7R) antagonist with Ki of 7.6 nM in competitive binding assays. |
| PC-26569 |
UB-ALT-P2
P2X7 antagonist
|
UB-ALT-P2 is a potent and selective brain-penetrant negative allosteric modulator / antagonist of ATP-gated P2X7 receptor (P2X7R) with IC50 of 1.3 nM. |
| PC-26328 |
Funopixant
P2X3 antagonist
|
Funopixant is a potent, selective P2X3 receptor antagonist with IC50 of 32.45 nM for hP2X3. |
| PC-26167 |
PSB-1011
P2X2 antagonist
|
PSB-1011 is a potent, moderately selective rat P2X2 receptor antagonist with IC50 of 79 nM, weakly inhibits P2X1 and P2X3 receptors and shows no activity against P2X4 and P2X7 receptors. |
| PC-26162 |
PSB-15417
P2X4 antagonist
|
PSB-15417 is a potent, specific P2X4 receptor (P2X4R) antagonist with IC50 of 21.9 nM and 37 nM for human and rat P2X4 receptor, shows limited activity against P2X1, P2X2, P2X3 and P2X7 receptors (All IC50>2 uM). |
| PC-26160 |
MRS4719
P2X4 antagonist
|
MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R. |
| PC-26159 |
PSB-0704
P2X4 antagonist
|
PSB-0704 is a potent, allosteric P2X4 receptor inhibitor with IC50 of 12.5 and 0.07 uM for human wt P2X4 and P2X4-E307T receptor mutant. |
| PC-25132 |
PPADS tetrasodium
P2X receptor antagonist
|
PPADS tetrasodiuma is a non-selective P2X receptor antagonist, inhibits recombinant P2X1, P2X12, P2X13, P2X15 with IC50 of 1-2.6 uM. |
| PC-22910 |
AZ11645373
P2X7 antagonist
|
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM. |
| PC-22645 |
GSK1482160
P2X7 NAM
|
GSK1482160 is an orally available allosteric P2X7 receptor negative allosteric modulator (NAM) with pIC50 of 8.5 and 6.5 for human and rat P2X7R respectively. |
