| Cat. No. |
Product Name |
Information |
| PC-27099 |
P2X7R antagonist A20
P2X7 antagonist
|
P2X7R antagonist A20 (Compound 9q) is a potent, selective antagonist of ATP-gated channel P2X7 receptor (P2X7R) with IC50 of 18 nM (hP2X7), exhibits non-competitive negative allosteric mode of antagonism. |
| PC-26569 |
UB-ALT-P2
P2X7 antagonist
|
UB-ALT-P2 is a potent and selective brain-penetrant negative allosteric modulator / antagonist of ATP-gated P2X7 receptor (P2X7R) with IC50 of 1.3 nM. |
| PC-26162 |
PSB-15417
P2X4 antagonist
|
PSB-15417 is a potent, specific P2X4 receptor (P2X4R) antagonist with IC50 of 21.9 nM and 37 nM for human and rat P2X4 receptor, shows limited activity against P2X1, P2X2, P2X3 and P2X7 receptors (All IC50>2 uM). |
| PC-26160 |
MRS4719
P2X4 antagonist
|
MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R. |
| PC-26159 |
PSB-0704
P2X4 antagonist
|
PSB-0704 is a potent, allosteric P2X4 receptor inhibitor with IC50 of 12.5 and 0.07 uM for human wt P2X4 and P2X4-E307T receptor mutant. |
| PC-25132 |
PPADS tetrasodium
P2X receptor antagonist
|
PPADS tetrasodiuma is a non-selective P2X receptor antagonist, inhibits recombinant P2X1, P2X12, P2X13, P2X15 with IC50 of 1-2.6 uM. |
| PC-22910 |
AZ11645373
P2X7 antagonist
|
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM. |
| PC-22645 |
GSK1482160
P2X7 NAM
|
GSK1482160 is an orally available allosteric P2X7 receptor negative allosteric modulator (NAM) with pIC50 of 8.5 and 6.5 for human and rat P2X7R respectively. |
| PC-21244 |
BX430
P2X4 antagonist
|
BX430 is a potent, highly selective and allosteric antagonist of P2X4 receptor channel with IC50 of 0.54 uM. |
| PC-20741 |
BLU-5937
P2X3 antagonist
|
BLU-5937 (Camlipixant, BLU5937) is a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist with IC50 of 25 and 92 nM for human and rat P2X3 receptors, repsectively. |
| PC-20738 |
Filapixant
P2X3 antagonist
|
Filapixant (BAY1902607) is a potent, selective P2X3 receptor antagonist, shows a substantially higher in vitro selectivity for P2X3 over P2X2 when compared with Eliapixant (BAY1817080, Cat# PC-72754). |
| PC-49765 |
NF449
P2X1 antagonist
|
NF449 (NF-449) is a highly potent, selective and reversible competitive human P2X1 receptor antagonist with IC50 of 0.05 nM. |
