| Cat. No. |
Product Name |
Information |
| PC-26163 |
BzATP triethylammonium salt
P2X receptors agonist
|
BzATP triethylammonium salt is a broad P2X receptors agonist with pEC50 values of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. |
| PC-26161 |
PSB-12062
P2X4 antagonist
|
PSB-12062 is a potent, specific P2X4 receptor antagonist with IC50 of 1.38 uM, >35-fold selective over P2X1, P2X2, P2X3 and P2X7 receptors. |
| PC-26158 |
Cibacron Blue
P2X receptor modulator
|
Cibacron Blue is a non-selective allosteric modulator of P2X2, P2X3, and P2X4 receptors, shows anti-inflammatory and antiarthritic, anti-cancer activites, also inhibits R46 β-lactamase with Ki of 1.2 uM. |
| PC-25895 |
PSFL1191
hP2X7 antagonist
|
PSFL1191 is a potent, species-specific inhibitor for human and panda P2X7 receptors with IC50 of 248 nM (hP2X7) and 754 nM (pdP2X7), but inactive against rodents P2X7 (mP2X7/rP2X7, IC50>30 uM). |
| PC-25894 |
GW791343
P2X7 antagonist
|
GW791343 dihydrochloride is a selective, allosteric antagonist with negative allosteric effects at the human P2X7 receptor with pIC50 of 6.9-7.2, but is a positive allosteric modulator of the rat P2X(7) receptor. |
| PC-25643 |
Gefapixant citrate
P2X3 antagonist
|
Gefapixant citrate (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer). |
| PC-25573 |
HW091077
P2X3 antagonist
|
HW091077 is a potent, selective P2X3 receptor (P2X3R) antagonist with IC50 of 17 nM, shows balanced selectivity versus P2X2/3 (IC50=190 nM). |
| PC-25572 |
UB-MBX-46
P2X7 antagonist
|
UB-MBX-46 is a potent, selective and allosteric antagonist of human P2X7 receptor (hP2X7R) antagonist with IC50 of 0.514 nM, 40.6 nM and 4.52 nM for human, rat and mouse P2X7R respectively. |
| PC-25029 |
Relicpixant
P2X3 antagonist
|
Relicpixant is a potent, selective P2X3 receptor antagonist. |
| PC-24035 |
Brilliant Blue G
P2X7 antagonist
|
Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, also is a highly selective P2X7 receptor antagonist. |
| PC-24034 |
ITH15004
P2X7 antagonist
|
ITH15004 is potent, selective, and BBB-permeable antagonist of ATP-gated P2X7 purinergic receptor (P2X7) with IC50 of 9 uM. |
| PC-22526 |
NP-1815-PX sodium
P2X4 antagonist
|
NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM. |
