| Cat. No. |
Product Name |
Information |
| PC-60767 |
JNJ-42253432
P2X7 antagonist
|
JNJ-42253432 is a potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
| PC-70094 |
AZD9056
P2X7 antagonist
|
AZD9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45634 |
AZD9056 hydrochloride
P2X7 antagonist
|
AZD9056 hydrochloride (AZD-9056) is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM. |
| PC-45846 |
A-740003
P2X7 antagonist
|
A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively. |
| PC-42169 |
A-804598
P2X7 antagonist
|
A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively. |
| PC-27706 |
MRS2339
P2X receptor agonist
|
MRS2339 is a nucleotide analog agonist of cardiac P2X receptor, improves systolic function in heart failure. |
| PC-27681 |
P2X2/3 antagonist 30
P2X2/3 antagonist
|
P2X2/3 antagonist 30 is a potent, selective and allosteric antagonist with pIC50 of 8.4 (hP2X2/3), shows efficacious taste-blocking effect. |
| PC-27427 |
Femopixant
P2X2/3 antagonist
|
Femopixant is a potent, selective P2X3 and P2X2/3 receptor antagonist. |
| PC-27056 |
BTFA
P2X1 receptor inhibitor
|
BTFA is a specific small molecule P2X1 receptor inhibitor, binds to the top of the central vestibule and inhibits cation flux in a dose-dependent manner, inhibits the mixed-cation current of the mP2X1 receptor with IC50 of 4.3 uM. |
| PC-26169 |
PSB-OR-2020
P2X4 antagonist
|
PSB-OR-2020 is a potent, selective P2X4 receptor antagonist, inhibits ATP-induced Ca2+ influx by in 1321N1 astrocytoma cells stably transfected with the human P2X4 receptor with IC50 of 6.32 nM, >300-fold selective over P2X1, P2X2, P2X3, and P2X7. |
| PC-26168 |
A-317491
P2X3 antagonist
|
A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. |
| PC-26166 |
PSB-2014
P2X1 antagonist
|
PSB-2014 is a potent, selective and competitive P2X1 receptor (P2X1R) with IC50 of 23.1 nM, weakly inhibits P2X4, P2X7 and shows no activity against P2X2, P2X3 receptors. |
