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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-A-317491
A-317491

Chemical Structure : A-317491

CAS No.: 475205-49-3

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A-317491 (A317491)

货号: PC-26168Not For Human Use, Lab Use Only.

A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively.
A-317491 is highly selective over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50>10 μM).
A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

物理化学性质&存储条件

分子量 565.58
分子式 C33H27NO8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-((3-Phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid

参考文献

1. Jarvis MF, et, al. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84.

2. Wu G, et, al. Eur J Pharmacol. 2004 Nov 3;504(1-2):45-53.

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