MRS4719 | P2X4 antagonist | Probechem Biochemicals

Chemical Structure : MRS4719

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MRS4719 (MRS-4719)

货号: PC-26160Not For Human Use, Lab Use Only.

MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R.

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生物&药学活性

MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R.
MRS4719 showed neuroprotective and learning- and memory-enhancing activities in a mouse middle cerebral artery occlusion (MCAO) model of ischemic stroke.
MRS4719 also reduced ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages.

物理化学性质&存储条件

分子量	504.61
分子式	C26H28N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione, 5-[2-(2,5-dihydro-5-thioxo-1,2,4-oxadiazol-3-yl)-4-pyridinyl]-, compd. with N,N-diethylethanamine (1:1)

参考文献

1. Kiran S Toti, et al. J Med Chem. 2022 Oct 27;65(20):13967-13987.

MRS4719 (MRS-4719)

生物&药学活性

物理化学性质&存储条件

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MRS4719 (MRS-4719)

生物&药学活性

物理化学性质&存储条件

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