| Cat. No. |
Product Name |
Information |
| PC-20901 |
YLIU-5-162-1
JAK2 inhibitor
|
YLIU-4-105-1 is a novel type II JAK2 inhibitor, binds to JAK2 kinase domain (JH1), show potential for overcoming acquired resistance to ruxolitinib. |
| PC-20516 |
TAK-279
TYK2 inhibitor
|
TAK-279 (Zasocitinib, NDI-034858) is a potent, selective and allosteric TYK2 inhibitor, targets TYK2 JH2 domain with binding KD of 3.8 pM. |
| PC-20143 |
CEE321
pan JAK inhibitor
|
CEE321 (CEE-321) is a potent, selective pan-JAK inhibitor with IC50 of 50, 48, 59 and 48 nM for JAK1, JAK2, JAK3 and TYK2, respectively. |
| PC-20060 |
Nimucitinib
JAK inhibitor
|
Nimucitinib is a potent, selective Janus kinase (JAK) inhibitor. |
| PC-49651 |
CPL409116
JAK/ROCK inhibitor
|
CPL409116 (CPL'116, CPL 409116) is a potent, competitive, dual JAK and ROCK inhibitor with IC50 of 0.95/5.36//0.87/110.6/106.7 nM for JAK1/JAK2/JAK3/ROCK1/ROCK2, respectively. |
| PC-49397 |
Ifidancitinib
JAK1/3 inhibitor
|
Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling. |
| PC-49377 |
JAK-IN-21
JAK inhibitor
|
JAK-IN-21 is a selective and potent JAK inhibitor with IC50 of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively. |
| PC-49343 |
VVD-118313
JAK1 inhibitor
|
VVD-118313 (VVD118313) is a potent, selective and allosteric inhibitor of the non-catalytic pseudokinase domain of JAK1 (C817), blocks JAK1-dependent trans-phosphorylation and cytokine signaling. |
| PC-49307 |
AZD0449
JAK1 inhibitor
|
AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3. |
| PC-49274 |
Z583
JAK3 inhibitor
|
Z583 is a potent, highly selective JAK3 inhibitor with IC50 of 0.1 nM, 4500-fold selectivity over other JAK subtypes. |
| PC-49112 |
TYK2-JH1 inhibitor 30
TYK2-JH1 inhibitor
|
TYK2-JH1 inhibitor 30 is a potent and selective TYK2-JH1 inhibitor with Ki of 0.51 nM. |
| PC-38399 |
Ilunocitinib
JAK inhibitor
|
Ilunocitinib (LY-3411067) is a potent, small molecule JAK inhibitor. |
