| Cat. No. |
Product Name |
Information |
| PC-45448 |
Filgotinib
JAK1/2 inhibitor
|
Filgotinib (GLPG 0634) is a potent JAK1/JAK2 inhibitor with IC50 of 10 nM/28 nM in biochemical assays, less potent for JAK3 and TYK2. |
| PC-44289 |
BMS-911543
JAK2 inhibitor
|
BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM. |
| PC-42753 |
CYT387 mesylate
JAK1/2 inhibitor
|
Momelotinib mesylate (CYT387 mesylate) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM. |
| PC-42752 |
CYT387 sulfate
JAK1/2 inhibitor
|
Momelotinib (CYT387) sulfate is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM. |
| PC-42751 |
CYT387
JAK1/2 inhibitor
|
Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM. |
| PC-45123 |
Itacitinib
JAK1 inhibitor
|
Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively. |
| PC-27282 |
TYK2 activator 6g
TYK2 activator
|
TYK2 activator 6g is a potent, selective small molecule TYK2 activator with EC50 of 0.21 uM (JH1/JH2 TYK2), maximal activation effect (Emax) of 7.8-fold. |
| PC-27281 |
HHT-9041P1
JAK1 inhibitor
|
HHT-9041P1 is a potent and selective JAK1 inhibitor with IC50 of 612 nM, displays 10-, 23- and 63-fold selective over JAK2, JAK3 and TYK2. |
| PC-26419 |
JAK1 inhibitor AZ-3
JAK1 inhibitor
|
JAK1 inhibitor AZ-3 is a potent, selective and orally efficacious JAK1 inhibitor with IC50 of 3.4 nM, >1000-fold selective over JAK2 , JAK3 and TYK2. |
| PC-26418 |
YYSW001
JAK1 inhibitor
|
YYSW001 is a potent, highly selective and orally bioavailable JAK1 inhibitor with IC50 of 6 nM, with no activity against JAK2 and JAK3. |
| PC-26362 |
Vexicitinib
JAK inhibitor
|
Vexicitinib is a potent, selective JAK inhibitor with anti-inflammatory and immunosuppressant activities. |
| PC-26345 |
Nomelcitinib
Tyk2 inhibitor
|
Nomelcitinib (D-2570) is a potent, selective tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the JH2 domain of TYK2. |
