PF-06263276 | JAK inhibitor | ProbeChem Biochemicals

Chemical Structure : PF-06263276

CAS No.: 1421502-62-6

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PF-06263276 (PF 06263276, PF06263276, PF-6263276)

货号: PC-60312Not For Human Use, Lab Use Only.

PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
PF-06263276 demonstrates good JAK potency and kinase selectivity.
PF-06263276 exhibts inhibitory potency in human whole blood versus various stimulatory cytokines (IFNα, IL-23, IL-4, IL-6 and GM-CSF) with IC50 of 0.6-5.2 uM.
PF-06263276 is suitable for inhaled and topical delivery in vivo.

物理化学性质&存储条件

分子量	566.64
分子式	C31H31FN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone

参考文献

1. Jones P, et al. J Med Chem. 2017 Jan 26;60(2):767-786.

PF-06263276 (PF 06263276, PF06263276, PF-6263276)

生物&药学活性

物理化学性质&存储条件

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PF-06263276 (PF 06263276, PF06263276, PF-6263276)

生物&药学活性

物理化学性质&存储条件

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