| Cat. No. |
Product Name |
Information |
| PC-38210 |
BMS-986202
TYK2 inhibitor
|
BMS-986202 (BMS 986202) is potent, selective Tyk2 inhibitor that binds to Tyk2 JH2 domain with IC50 of 0.19 nM, Ki of 0.02 nM, >10,000-fold over 273 kinases and pseudokinases. |
| PC-38049 |
GDC-046
TYK2 inhibitor
|
GDC-046 is a potent, selective, and orally bioavailable inhibitor of TYK2 with with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively. |
| PC-38034 |
FM479
|
FM-479 is an FM-381 structural analog, the negative control of FM-381 and has no activity on JAK3 or other kinases. |
| PC-38006 |
Flonoltinib maleate
JAK2/FLT3 inhibitor
|
Flonoltinib maleate is a potent, highly selective, dual JAK2/FLT3 inhibitor with IC50 of 0.8, 1.4, and 15 nM for JAK2, JAK2V617F, and FLT3, respectively. |
| PC-38005 |
Flonoltinib
JAK2/FLT3 inhibitor
|
Flonoltinib is a potent, highly selective, dual JAK2/FLT3 inhibitor with IC50 of 0.8, 1.4, and 15 nM for JAK2, JAK2V617F, and FLT3, respectively. |
| PC-36069 |
ZT55
JAK2 inhibitor
|
ZT55 (JAK inhibitor ZT55) is a novel potent, highly-selective tyrosine kinase JAK2 inhibitor with IC50 of 31 nM. |
| PC-35842 |
SAR-20347
JAK1/Tyk2 inhibitor
|
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM). |
| PC-35830 |
iJak-381
JAK1 inhibitor
|
iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2. |
| PC-35502 |
JAK2 inhibitor G5-7
JAK2 inhibitor
|
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
| PC-63575 |
FM-381
JAK3 inhibitor
|
FM-381 (FM381) is a potent, specific, reversible and covalent inhibitor of JAK3 with IC50 of 127 pM, 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and Tyk2, respectively. |
| PC-43343 |
LY2784544
JAK2 V617F inhibitor, GPR39 agonist
|
LY2784544 (Gandotinib) is a potent, selective and ATP-competitive inhibitor of JAK2 V617F, effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50=20 and 55 nM, respectively). |
| PC-63194 |
Atiprimod dihydrochloride
JAK2 inhibitor
|
Atiprimod (SKF 106615, Azaspirane) is a potent, orally bioavailable JAK2 inhibitor, inhibits phosphorylation of JAK2 and the downstream STAT3 and STAT5 pathways. |
