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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-GDC-4379
GDC-4379

Chemical Structure : GDC-4379

CAS No.: 2252277-73-7

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GDC-4379 (GDC4379)

货号: PC-21215Not For Human Use, Lab Use Only.

GDC-4379 is a potent, selective and inhaled JAK inhibitor with IC50 of 2 nM and 36 nM for JAK1 and JAK2 respectively, reduces FeNO and peripheral biomarkers of inflammation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GDC-4379 is a potent, selective and inhaled JAK inhibitor with IC50 of 2 nM and 36 nM for JAK1 and JAK2 respectively, reduces FeNO and peripheral biomarkers of inflammation.

    物理化学性质&存储条件

    分子量 489.87
    分子式 C21H18ClF2N7O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(dimethylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-

    参考文献

    1. Chen H, et al. Pulm Pharmacol Ther. 2022 Aug;75:102133.

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