| Cat. No. |
Product Name |
Information |
| PC-45123 |
Itacitinib
JAK1 inhibitor
|
Itacitinib (INCB-039110) is a potent and selective, orally bioactive JAK1 inhibitor with IC50 of 2 nM, shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively. |
| PC-27384 |
KMU-11342
Multikinase inhibitor
|
KMU-11342 is a novel multi-protein kinase inhibitor, inhibits inflammatory protein kinases including IKKα(h), IKKβ(h), JAK1(h), JAK2(h), JAK3(h), MAPK1(h), JNK3(h), TAK1(h), and TYK2(h) with IC50 of <1 uM, mitigates LPS-mediated inflammatory responses in THP-1 cells by inhibiting the activation of NLRP3 inflammasome. |
| PC-26419 |
JAK1 inhibitor AZ-3
JAK1 inhibitor
|
JAK1 inhibitor AZ-3 is a potent, selective and orally efficacious JAK1 inhibitor with IC50 of 3.4 nM, >1000-fold selective over JAK2 , JAK3 and TYK2. |
| PC-26217 |
Deuruxolitinib
JAK1/2 inhibitor
|
Deuruxolitinib is the deuterated form of Ruxolitinib, is an orally active JAK1 and JAK2 inhibitor. |
| PC-26019 |
NS-229 hydrochloride
JAK1 inhibitor
|
NS-229 hydrochloride is a potent, selective JAK1 inhibitor with IC50 of 52 nM. |
| PC-26018 |
NS-229 4-methylbenzenesulfonate monohydrate
JAK1 inhibitor
|
NS-229 4-methylbenzenesulfonate monohydrate is a potent, selective JAK1 inhibitor with IC50 of 52 nM. |
| PC-25103 |
Voderdeucitinib
TYK2 inhibitor
|
Voderdeucitinib is a potent selective TYK2 inhibitor. |
| PC-24148 |
Lirucitinib hydrochloride
JAK inhibitor
|
Lirucitinib hydrochloride is a potent, selective JAK inhibitor. |
| PC-23784 |
Dual JAK3-TEC kinase inhibitor ZZB
JAK3/TEC kinase inhibitor
|
Dual JAK3-TEC kinase inhibitor ZZB is a potent, selective, covalent dual JAK3/TEC family kinases inhibitor with IC50 of 0.80 nM against JAK3 and 11.56 nM against TEC kinase interleukin-2-inducible T-cell kinase (ITK) respectively. |
| PC-22994 |
SB1578
JAK2/FLT3 inhibitor
|
SB1578 is a potent, selective JAK2/FLT3 inhibitor with IC50 of 46/60 nM respectively. |
| PC-22618 |
Oclacitinib maleate
JAK inhibitor
|
Oclacitinib (PF-03394197) maleate is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-21281 |
QL-1200186
TYK2-JH2 inhibitor
|
QL-1200186 is a potent, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 0.06 nM, targets pseudokinase regulatory domain (Janus homology 2, JH2) of the TYK2 protein. |
