JAK1 inhibitor AZ-3

Chemical Structure : JAK1 inhibitor AZ-3

加入收藏

货号: PC-26419Not For Human Use, Lab Use Only.

JAK1 inhibitor AZ-3 is a potent, selective and orally efficacious JAK1 inhibitor with IC50 of 3.4 nM, >1000-fold selective over JAK2 , JAK3 and TYK2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JAK1 inhibitor AZ-3 is a potent, selective and orally efficacious JAK1 inhibitor with IC50 of 3.4 nM, >1000-fold selective over JAK2 , JAK3 and TYK2.
AZ-3 exhibits potent inhibition of pSTAT3 in NCI-H1975 cells with IC50 of 30 nM.
AZ-3 (1, 3, 10, 30, 50, and 100 mg/kg, oral gavage) induced a dose-dependent decrease in pSTAT3 in NCI-H1975 mouse xenograft model.

物理化学性质&存储条件

分子量	385.49
分子式	C20H28FN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-((R)-sec-butyl)-N2-(2-fluoro-5-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-yl)-5-methylpyrimidine-2,4-diamine

参考文献

1. Grimster NP, et al. J Med Chem. 2018 Jun 28;61(12):5235-5244.