OB756 (Bonretinib)

Chemical Structure : OB756

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货号: PC-25681Not For Human Use, Lab Use Only.

OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway.

物理化学性质&存储条件

分子量	399.47
分子式	C18H21N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)piperidin-4-yl)acetonitrile

参考文献

1. Yile Zhou MD, et al. Blood. Volume 144, Supplement 1, 5 November 2024, Page 1808.

2. Jian Huang, et al. Cancer. 2025 Oct 15;131(20):e70101.