NMS-P953

Chemical Structure : NMS-P953

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货号: PC-24735Not For Human Use, Lab Use Only.

NMS-P953 is a potent and selective JAK2 inhibitor with IC50 of 8 nM, displays 18-, 4- and 18-fold selective over JAK1, JAK3 and TYK2 respectively.

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生物&药学活性

NMS-P953 is a potent and selective JAK2 inhibitor with IC50 of 8 nM, displays 18-, 4- and 18-fold selective over JAK1, JAK3 and TYK2 respectively.
NMS-P953 exhibits good potency in SET-2 antiproliferative assay with IC50 of 0.48 uM.
NMS-P953 displays significant tumour growth inhibition in SET-2 xenograft tumour model.

物理化学性质&存储条件

分子量	381.74
分子式	C16H11ClF3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-3-carboxamide, 5-(2-amino-4-pyrimidinyl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-

参考文献

1. Brasca MG, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4998-5012.

NMS-P953

生物&药学活性

物理化学性质&存储条件

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NMS-P953

生物&药学活性

物理化学性质&存储条件

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