cTYK2i Compound-A

Chemical Structure : cTYK2i Compound-A

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货号: PC-24348Not For Human Use, Lab Use Only.

cTYK2i Compound-A (Cmpd-A) is a potent, specific and brain-penetrant TYK2 inhibitor (cTYK2i) with IC50 of 6.4 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

cTYK2i Compound-A (Cmpd-A) is a potent, specific and brain-penetrant TYK2 inhibitor (cTYK2i) with IC50 of 6.4 nM.
Cmpd-A is selective for the TYK2 JH2 domain versus all other tested JAK domains
Cmpd-A inhibits IL-6-induced pSTAT3 and GM-CSF-induced pSTAT5 with IC50 of 6.4 nM and 8.0 nM respectively.
Cmpd-A reduced type I IFN pathway activity in the brain.
Cmpd-A is protective by semitherapeutic delivery in the MOG35-55 EAE mouse model, reduces demyelination and gliosis.
Cmpd-A attenuates transcriptional inflammatory program and biomarker expression in EAE mouse models.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Tyler P Molitor, et al. Proc Natl Acad Sci U S A. 2025 Apr;122(13):e2422172122.