NS-229 (NS229)

Chemical Structure : NS-229

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货号: PC-26017Not For Human Use, Lab Use Only.

NS-229 is a potent, selective JAK1 inhibitor with IC50 of 52 nM.

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生物&药学活性

NS-229 is a potent, selective JAK1 inhibitor with IC50 of 52 nM.
NS-229 significantly decreased the expression of CD69 induced by IL-5 in human peripheral blood eosinophils.
NS-229 significantly decreased the production of cytokines such as interferon gamma, IL-5, and IL-13, induced by anti-CD3/CD28 antibody, in human peripheral blood mononuclear cells.
NS-229 shows suppression of multiple cytokine signals and inhibition of vascular lesion formation without impacting the relevant side-effect parameters.

物理化学性质&存储条件

分子量	469.56
分子式	C22H27N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-(1-(6-((1-cyclopropylethyl)amino)-2-(pyrazolo[5,1-b]thiazol-7-yl)pyrimidine-4-carbonyl)piperidin-4-yl)carbamate

参考文献

1. Patent WO2016035814 A1 (Compound II).

2. Kageyama K, et al. J Pharmacol Exp Ther. 2026 Jan 7;393(2):103806.

NS-229 (NS229)

生物&药学活性

物理化学性质&存储条件

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NS-229 (NS229)

生物&药学活性

物理化学性质&存储条件

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