| Cat. No. |
Product Name |
Information |
| PC-28540 |
FIIN-4
FGFR inhibitor
|
FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50 of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. |
| PC-28539 |
FIIN-1
FGFR inhibitor
|
FIIN-1 is a potent, selective and covalent FGFR inhibitor with Kd values of 2.8/6.9/5.4/120 nM and 32/120 nM for FGFR1/2/3/4 and Flt1/4 respectively, inhibits FGFR1/2/3/4 with IC50 of 9.2, 6.2, 11.9, and 189 nM. |
| PC-28538 |
CXF-007
FGFR4 inhibitor
|
CXF-007 is a potent, selective covalent inhibitor of FGFR4 with IC50 of 7 nM, shows much weaker activity against FGFR1-3 with IC50 of 150-400 nM. |
| PC-28537 |
FGFR2-FGFR4 inhibitor F-30
FGFR2/4 inhibitor
|
FGFR2-FGFR4 inhibitor F-30 is a potent, selective covalent inhibitor of FGFR2/4 with IC50 of 7.8 nM and 11 nM for FGFR2 and FGFR4 respectively. |
| PC-28171 |
Formononetin
FGFR2 inhibitor
|
Formononetin (Flavosil, Biochanin B, Formononetol) is a natural isoflavonoid with potential anti-angiogenic and anti-cancer activities, directly inhibits FGFR2 kinase activity with IC50 of 4.31 uM. |
| PC-27886 |
LC-F2-1
FGFR2 inhibitor
|
LC-F2-1 is a potent, covalent FGFR2-selective inhibitor with IC50 of 10.0 and 5.8 nM for FGFR2 WT and V565F gatekeeper mutant respectively, has 21-fold selectivity for FGFR1 and >1000-fold for FGFR4 in biochemical assays. |
| PC-27469 |
Lavengratinib
FGFR2/3 inhibitor
|
Lavengratinib (ABSK061) is a potent, highly selective oral FGFR2/3 inhibitor, including secondary FGFR2/3 kinase domain mutations as well as off-target alterations in RTK/RAS and DDR pathways. |
| PC-27122 |
CYB-5067
pan-FGFR molecular glue
|
CYB-5067 is a potent, covalent RNF213-recruiting molecular glue degrader of pan-FGFR with DC50 of 430 nM, 27 nM, 314 nM and 596 nM for FGFR1, 2, 3 and 4. |
| PC-26354 |
Risimtinib
FGFR inhibitor
|
Risimtinib (Compound 19a) is a highly potent FGFR inhibitor with IC50 of 2.1 nM against FGFR1, and 14.9 nM against the FGFR1-positive KG-1cancer cell. |
| PC-25666 |
LOXO-435
FGFR3 inhibitor
|
Vepugratinib (LOXO-435, LY-3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations. |
| PC-24953 |
HMPL-453
FGFR1/2/3 inhibitor
|
HMPL-453 (Fanregratinib) is a potent, highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 (FGFR1/2/3) with IC50 of 6, 4, and 6 nM, respectively, shows weaker activity against FGFR4 (IC50=425 nM). |
| PC-24894 |
INCB126503
FGFR2/3 inhibitor
|
INCB126503 is a highly potent, selective, orally bioavailable FGFR2/3 inhibitor with IC50 of 2.1/1.2 nM respectively. |
