LOXO-435 (LY3866288)

Chemical Structure : LOXO-435

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货号: PC-25666Not For Human Use, Lab Use Only.

LOXO-435 (LY3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

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250 mg		Get quote

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生物&药学活性

LOXO-435 (LY3866288) is a potent, highly isoform-selective FGFR3 inhibitor, inhibits both wild-type and oncogenically activated FGFR3, including FGFR3 fusions, point mutations, and acquired gatekeeper resistance mutations.

物理化学性质&存储条件

分子量	496.93
分子式	C23H22ClFN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(4-(3-chloro-4-(1-(5-fluoropyridin-2-yl)-2-hydroxyethoxy)pyrazolo[1,5-a]pyridin-6-yl)-5-methyl-1H-1,2,3-triazol-1-yl)piperidine-1-carbonitrile

参考文献

1. Gopa Iyer, et al. Cancer Res (2023) 83 (8_Supplement): CT119.

2. Patent WO2022187443 A1.