CXF-007 (CXF007)

Chemical Structure : CXF-007

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货号: PC-28538Not For Human Use, Lab Use Only.

CXF-007 is a potent, selective covalent inhibitor of FGFR4 with IC50 of 7 nM, shows much weaker activity against FGFR1-3 with IC50 of 150-400 nM.

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生物&药学活性

CXF-007 is a potent, selective covalent inhibitor of FGFR4 with IC50 of 7 nM, shows much weaker activity against FGFR1-3 with IC50 of 150-400 nM.
CXF-007 has IC50 of 530 nM, 445 nM, 170 nM and 1 nM for FGFR1/2/3/4 in Ba/F3 cells in Ba/F3 cell-viability assays, respectively.
CXF-007 potentially overcomes FGFR4 cysteine mutants, exhibits high activity against mutants against FGFR4(C477A), FGFR4(C552A) and FGFR4(C477A, C552A) with IC50 of 29 nM, 113 nM and 205 nM, respectively.
CXF-007 forms covalent bonds with Cys552 of FGFR4.
CXF-007 potently inhibits proliferation and FGFR4 signaling in cancer cell lines with abnormal FGFR4 expression (MDA-MB-453, IC50=0.37 uM).

物理化学性质&存储条件

分子量	619.68
分子式	C34H33N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((8-(4-acrylamidophenethyl)-6-(3,5-dimethoxyphenyl)-7-oxo-5,6,7,8-tetrahydropyrimido [4,5-d] pyrimidin-2-yl) amino) phenyl) acrylamide

参考文献

1. Xiaojuan Chen, et al. Eur J Med Chem. 2024 Mar 15:268:116281.

CXF-007 (CXF007)

生物&药学活性

物理化学性质&存储条件

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CXF-007 (CXF007)

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物理化学性质&存储条件

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