| Cat. No. |
Product Name |
Information |
| PC-45537 |
Erdafitinib
FGFR inhibitor
|
Erdafitinib (JNJ-42756493) is a highly potent and selective, small-molecule inhibitor of FGFR family with IC50s of 1.2/2.5/3/5.7 nM for FGFR1/2/3/4. |
| PC-42406 |
FGF-401
FGFR4 inhibitor
|
FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM. |
| PC-26972 |
KNT-0919
FGFR2/3 inhibitor
|
KNT-0919 is a potent, selective and covalent FGFR2/3 inhibitor, potently suppresses FGFR2- and FGFR3-driven Ba/F3 cells with IC50 of 1.1 nM and 0.20 nM respectively. |
| PC-26356 |
SOMCL-286
FGFR/VEGFR inhibitor
|
SOMCL-286 (Compound 25a) is a highly potent dual FGFR/VEGFR inhibitor with IC50 of 1.0 nM against FGFR1, shows nearly equally high potency against FGFR1, FGFR2 and VEGFR-2 with IC50 values of 1.0, 4.5 and 2.9 nM, respectively. |
| PC-26355 |
SOMCL-085
FGFR inhibitor
|
SOMCL-085 is a potent multi-targeted FGFR inhibitor with IC50 of 1.8, 1.9 and 6.9 nM for FGFR1-3, simultaneously inhibits VEGFR and PDGFR. |
| PC-26084 |
FGFR3 covalent inhibitor 10s
FGFR3 inhibitor
|
FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4. |
| PC-25243 |
TCB-32
bFGF mimic, FGFR1 activator
|
TCB-32 is an agonistic small molecules that mimic binding of basic fibroblast growth factor (bFGF), shows a strong proliferative effect in NIH 3T3 cells, activates the same FGFR1-signaling pathway as bFGF. |
| PC-22625 |
FGF trap compound 57
FGF trap inhibitor
|
FGF trap compound 57 is a non-steroidal NSC12 derivative as FGF trap small molecule, shows anti-myeloma activity. |
