FGFR3 covalent inhibitor 10s

Chemical Structure : FGFR3 covalent inhibitor 10s

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货号: PC-26084Not For Human Use, Lab Use Only.

FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

FGFR3 covalent inhibitor 10s is a selective, covalent FGFR3 inhibitor with IC50 of 6.8 nM, has 5-60-fold selectivity over FGFR1/2/4.
FGFR3 covalent inhibitor 10s is also effective against the common clinically acquired FGFR3V555M resistance mutation with an IC50 value of 19.2 nM.
FGFR3 covalent inhibitor 10s exhibited strong antiproliferative effects in FGFR3-driven RT112/84 cells (IC50 = 9.2 nM).
FGFR3 covalent inhibitor 10s (10-20 mg/kg) showed significant antitumor efficacy in the RT112/84 bladder cancer xenograft model.

物理化学性质&存储条件

分子量	486.58
分子式	C26H30N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-methyl-3-(2-((5-methyl-1-(2-morpholinoethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indol-6-yl)acrylamide

参考文献

1. Wenjian Zhu, et al. J Med Chem. 2026 Feb 6. doi: 10.1021/acs.jmedchem.5c02552.