| Cat. No. |
Product Name |
Information |
| PC-27961 |
Nebivolol
Beta adrenergic antagonist
|
Nebivolol (R 065824) is a beta adrenergic antagonist and shows direct vasodilator properties and adrenergic blocking characteristics. |
| PC-27379 |
ICI-118551 hydrochloride
β2-adrenergic receptor antagonist
|
ICI-118551 hydrochloride (Zenidolol) is a potent, selective β2-adrenergic receptor (ADRB2, beta(2)-AR) antagonist with Ki of 0.7, 49.5 and 611 nM for β2, β1 and β3 adrenergic receptors respectively. |
| PC-27378 |
ICI-118551
β2-adrenergic receptor antagonist
|
ICI-118551 (Zenidolol) is a potent, selective β2-adrenergic receptor (ADRB2, beta(2)-AR) antagonist with Ki of 0.7, 49.5 and 611 nM for β2, β1 and β3 adrenergic receptors respectively. |
| PC-27361 |
Dexmedetomidine
α2-adrenoceptor agonist
|
Dexmedetomidine is a potent, selective agonist of α2-adrenergic receptor (α2-adrenoceptor) with Ki of 1.08 nM, >1000-fold selectivity against α1-adrenoceptor. |
| PC-27360 |
Tizanidine
α2-adrenoceptor agonist
|
Tizanidine is a skeletal muscle relaxant and an orally effective central α2-adrenoceptor agonist (IC50=6 nM), exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons, also inhibits the proliferation, migration, and invasion of lung cancer cells. |
| PC-27223 |
Alfuzosin hydrochloride
α1-adrenoceptor antagonist
|
Alfuzosin (SL 77499) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist, shows potential for prostatic hyperplasia (BPH). |
| PC-27222 |
Alfuzosin
α1-adrenoceptor antagonist
|
Alfuzosin (SL 77499) is an orally active, selective and competitive α1-adrenoceptor antagonist, shows potential for prostatic hyperplasia (BPH). |
| PC-27221 |
Doxazosin
α1-adrenoceptor antagonist
|
Doxazosin is a long-lasting, selective antagnist of α1-adrenoceptor antagonist receptors, shows potent apoptotic effect against prostate tumor epithelial cells, also has direct inhibitory effect on cholesterol synthesis independent of the LDL receptor. |
| PC-26994 |
SOM3355
β1-adrenergic receptor antagonist
|
Bevantolol hydrochloride (SOM3355) is a CNS-permeant, selective β1-adrenergic receptor antagonist with pKi value of 7.83 in rat cerebral cortex, also shows additional VMAT2 and VMAT1 inhibition activity. |
| PC-26836 |
Terazosin
PGK1 activator, α1-adrenergic receptor antagonist
|
Terazosin is a small molecule α1-adrenergic receptor antagonist and activator of phosphoglycerate kinase 1 (PGK1) at 2.5 nM -0.5 uM, binds to PGK1 with ITC Kd of 2.78 uM. |
| PC-26658 |
RX821002
α2A/D-adrenoreceptor antagonist
|
RX821002 (2-Methoxyidazoxan) is a highly selective antagonist of alpha2A/D-adrenoreceptor (alpha2A/D-AR) antagonist with pKd of 8.2 and 9.7 for rabbit alpha 2A-adrenoceptor and guinea-pig alpha 2D-adrenoceptor respectively. |
| PC-26581 |
A-61603
α1A AR agonist
|
A-61603 is a potent, selective alpha 1-adrenergic receptor (α1A AR) agonist, >35-fold more potent at α1A than at α1B or α1D sites, induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro with EC50 of 6.9 nM. |
