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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-Tizanidine
Tizanidine

Chemical Structure : Tizanidine

CAS No.: 51322-75-9

Tizanidine

货号: PC-27360Not For Human Use, Lab Use Only.

Tizanidine is a skeletal muscle relaxant and an orally effective central α2-adrenoceptor agonist (IC50=6 nM), exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons, also inhibits the proliferation, migration, and invasion of lung cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tizanidine is a skeletal muscle relaxant and an orally effective central α2-adrenoceptor agonist (IC50=6 nM), exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons, also inhibits the proliferation, migration, and invasion of lung cancer cells.

物理化学性质&存储条件

分子量 253.71
分子式 C9H8ClN5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-amine

参考文献

1. Kamen L, et al. Curr Med Res Opin. 2008 Feb;24(2):425-39.

2. Granfors, M. T., et al. Br J Clin Pharmacol。 2004 Mar;57(3):349-53.

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